a tool for identifying drug-targetable redox-active disulphides

Alpha-defensin 14

Intermolecular

Cysteine 56 and cysteine 56

A redox-regulated disulphide may form between two units of Alpha-defensin 14 at cysteines 56 and 56 (6 and 6 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

47

PDB code

Structure name

high-resolution crystal structure of the mouse alpha-defensin cryptdin 14

Structure deposition date

2022-08-01

Thiol separation (Å)

8

Half-sphere exposure sum ?

68

Minimum pK_a ?

nan

% buried

nan

Peptide A name

Alpha-defensin 14

Peptide B name

Alpha-defensin 14

Peptide A accession

Peptide B accession

Peptide A residue number

56

Peptide B residue number

56

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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